Metabolic syndrome (MetS) alongside other related risk factors has been implicated as increasing an individual’s risk for cardiovascular disease and type 2 diabetes. MetS is associated with chronic low-grade inflammation and raised blood lipid levels, which have been shown to improve in individuals when put on a Nordic diet (ND). In this sub-study of the SYSDIET study, which was a 18-24 week randomised controlled multi centre study, the aim was to examine the effect of a ND compared to a control diet (CD) on genes that are involved in the production of inflammatory molecules and lipids. Blood samples of 88 obese participants from the SYSDIET study were analysed for various inflammatory molecule producing genes and lipid molecule producing genes. The results showed that compared to CD, ND increased the presence of the inflammatory gene RELA, but decreased the presence of inflammatory gene TNFRSF1A. No differences were observed in other inflammatory genes and no differences were observed in lipid producing genes. It was concluded that consuming a ND compared to a CD may affect the production of inflammatory genes; however further studies are required to determine if the ND improves the amount of blood lipids because of an altered presence of lipid producing genes. The implication of this for practitioners is that further research of the SYSDIET is needed. In addition, a Nordic diet may improve inflammation in obese individuals because of a reduction in the production of inflammatory genes.